Tandem au-catalyzed 3,3-rearrangement-[2 + 2] cycloadditions of propargylic esters: expeditious access to highly functionalized 2,3-indoline-fused cyclobutanes.
نویسنده
چکیده
The treatment of readily available propargylic indole-3-acetates with a catalytic amount of AuCl(PPh3)/AgSbF6 leads to tandem activations of the propargylic esters and the in situ generated allenylic esters, resulting in expeditious access to highly functionalized cyclobutanes with fused 2,3-indoline and gamma-lactone rings and an exocyclic E-double bond through sequential 3,3-rearrangement and [2 + 2] cyclization.
منابع مشابه
Enantioselective gold catalyzed dearomative [2+2]-cycloaddition between indoles and allenamides.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 48 شماره
صفحات -
تاریخ انتشار 2005